• Local way 76 towards Fabriano
• After about 80 Km in Fabriano drive into the S3 towards Foligno
• After about 125 km, before Foligno, drive into the local highway  S75 towards Perugia
• In Collestrada take the  E45 towards Rome and immediately after  1 Km go out in Ponte San Giovanni and drive into the S75 bis towards Perugia 
• Go out in Perugia San Faustino and then follow the city map

Around 160 Km for an average travel of 130 minutes.